As a classic calcium channel blocker, nifedipine was first marketed as a conventional tablet under the trade name “Xintongding”, a traditional clinical drug for the treatment of hypertension and angina pectoris. While this formulation can rapidly exert its antihypertensive effect, it is limited by formulation technology — its antihypertensive effect lasts only 4–5 hours, a relatively short duration, requiring three daily administrations.

After taking nifedipine conventional tablets, patients may experience side effects such as flushing, headache, palpitations, and tachycardia. Long-term administration may also cause gingival hyperplasia and ankle edema. Moreover, due to the short drug release duration of conventional tablets, multiple daily doses are needed, which leads to significant fluctuations in blood concentration. This not only fails to achieve stable blood pressure control but may also increase the risk of cardiovascular and cerebrovascular events, as well as induce side effects like headache and palpitations. Therefore, conventional nifedipine tablets are no longer recommended clinically as first-line long-term antihypertensive drugs.

Based on clinical needs and patients’ medication pain points, we focused on upgrading formulation technology, with particular attention to the core advantages of controlled-release formulations — advanced controlled-release technology enables the drug to be released at a steady, constant rate in the body, optimizing therapeutic efficacy and reducing the risk of adverse reactions.

Our product, JUPOPINE® Nifedipine Controlled-Release Tablets, not only extends the antihypertensive effect to 24 hours, achieving the therapeutic goal of “one dose a day for stable blood pressure control throughout the day” but also effectively avoids adverse reactions caused by fluctuations in blood concentration of conventional tablets, significantly reducing the incidence of adverse reactions. With only one daily dose, it greatly improves patient medication adherence, providing a safer, more effective, and more convenient treatment option for hypertensive patients.