As a technologically breakthrough preparation in the field of compound preparations, Jupoton® Loratadine and Pseudoephedrine Sulfate Sustained-Release Tablets innovatively adopts the immediate-release and sustained-release dual-layer composite formulation technology. By precisely separating the release profiles of the two core ingredients (Loratadine and Pseudoephedrine Sulfate), it meets the clinical demand for “rapid onset of action and long-lasting effect”.

The core difficulties of this technology lie in solving three major industry pain points: “compatibility between immediate-release and sustained-release layers, precise matching of release rates, and stability in industrial production”.

In terms of formulation design

Through hundreds of material screening and proportion optimization, our company has achieved two key goals. On one hand, the hydrophilic excipients used in the immediate-release layer can rapidly disintegrate and release within 30 minutes, allowing Loratadine and a small amount of Pseudoephedrine Sulfate to reach peak concentration quickly to relieve allergic symptoms. On the other hand, the sustained-release layer realizes the slow release of Pseudoephedrine Sulfate for up to 12 hours through a high-quality matrix sustained-release structure, maintaining stable and long-lasting efficacy.

In terms of process control

Our company imported high-precision dual-layer tablet presses from Germany. By precisely controlling the hardness difference and weight variation between the two layers of materials, we can avoid problems such as interlayer separation during tableting. Finally, we successfully achieved seamless bonding of the two functional layers, ensuring both the immediate therapeutic effect of the immediate-release layer (“rapid onset of action”) and the long-term release of the sustained-release layer.

Our technology not only breaks through the compatibility challenge of ingredients with different release characteristics in compound preparations but also ensures that the quality of each tablet meets national standards through strict quality control standards, demonstrating our company’s core technical strength in the field of modified-release preparations.